Louise Jefferson (née Mills) was a supporting character, portrayed by Emmy Award-winning actress Isabel Sanford, who appeared first on the television series All in the Family. She later became one of the main characters in its spinoff series, The Jeffersons. Her role lasted from 1971 to 1985, from her debut on All in the Family through the final episode of The Jeffersons. She was often referred to as "Weezie" by her on-screen husband, George Jefferson. She was first introduced on All in the Family as a neighbor of Archie and Edith Bunker. Sanford is one of the two actors to have appeared in all 253 episodes of the The Jeffersons.

Louise Jefferson appears on the cover of Entertainment Weezie magazine with rapper Lil Wayne that Donna reads in "Brown Magic".

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