- The Vas Deferens is the part of the testicles that is snipped during a vasectomy, as it conveys sperm from the testicles to the urethra. The title is a play on the phrase "a vast difference between men and women".
- When Donna claims she gained five pounds during her fake pregnancy, Cleveland responds with "Higher, Bob," a common contestant response in pricing games in The Price is Right under one time host Bob Barker.
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